| ncRNA name | Jagged-1 siRNA |
| ncRNA Category | siRNA |
| Disease name | cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | human lens epithelial cell line SRA01/04 |
| Methods | siRNA transfection, microarray, qPCR, Western blot, immunofluorescence staining, luciferase reporter assay |
| Expression pattern | associated |
| Functional description | Inhibition of Notch signaling by Jagged-1 siRNA and DAPT both abrogated the upregulation of EMT markers FN, Col IV, N-cadherin, α-SMA and EMT key transcription factors Snail, Slug and ZEB1 expression. Jagged-1 and blockade of Notch pathway can reverse TGFβ2-induced EMT phenotype in LECs. |
| PubMed ID | 28622289 |
| Year | 2017 |
| Title | MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway. |
| Drug-related ncRNA | NO |
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